GeoMx whole-transcriptome arm — the complete ion panel
The same screening logic applied to GeoMx's 7,619-gene whole transcriptome discovers ion-transporter genes — versus just 12 on the Xenium liver panel. This is the complete transporter complement: Na/K-ATPase, the V-ATPase proton pumps, the SLC4 bicarbonate family. The tradeoff: GeoMx resolves 47 regions, not single cells.
Zonal IEA: periportal → pericentral
Top zonal genes (whole-transcriptome only)
One donor liver, 4 regions × 3 zones, ~4 replicate ROIs each. Aggregate of screened ion genes. Modest magnitude, statistically robust, regionally unanimous.
Spatial Transcriptomics · SenNet / HuBMAP
One molecular ruler, three architectures of transport
Every cell in your body moves ions across its membranes — it is how the liver detoxifies, the pancreas secretes, the gut absorbs. The machinery is shared, but each organ arranges it differently.
We screened the same panel of ion-transporter genes across three human organs using one identical pipeline, then mapped the aggregate expression (IEA) onto every cell in space. The result is a portrait of how transport is organized — drawn from 375,000+ real cells.
The Ion-Transport Landscape
Every cell in a human liver section, mapped by its ion-transporter expression. 151,380 cells, each a single point.
Tissue
Color by
Transport flow
Legend
Each point is one segmented cell at its true spatial position, colored by transporter-marker cell type.
IEA = transcriptomic proxy · flow = expression gradient, not measured ion flux